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ID 111462
タイトル別表記
TWO PITUITARY ADENOMAS IN MEN 1
著者
Shintani, Yasumi The University of Tokushima
Horie, Hideaki The University of Tokushima
Kanesaki, Yoshiko The University of Tokushima
Hosoi, Emiko The University of Tokushima
Yokogoshi, Yutaka The University of Tokushima
板東, 浩 The University of Tokushima KAKEN研究者をさがす
Iwahana, Hiroyuki The University of Tokushima
Kannuki, Seiji The University of Tokushima
Matsumoto, Keizo The University of Tokushima
齋藤, 史郎 The University of Tokushima
キーワード
MEN 1
Pituitary adenoma
Ectopic GHRH-producing tumor
Loss of heterozygosity
Chromosome 11
資料タイプ
学術雑誌論文
抄録
The clinical and genetic features of a 43-year-old male patient with multiple endocrine neoplasia type 1 were reported. He developed hyperparathyroidism, a GHRH-producing pancreatic tumor, and acromegaly between 1980 and 1983. Because his pituitary gland increased in size even after resecting the GHRH-producing pancreatic tumor, transsphenoidal hypophysectomy was performed six years later. The pituitary contained two histologically-different adenomas composed of somatotroph cells and null cells. Genetic analyses revealed loss of heterozygosity on chromosome 11 in common in the pituitary adenomas, the pancreatic endocrine tumors, and a parathyroid hyperplasia. On the other hand, mutations of ras, p53, Gsα, and Gi2α genes were not found in these tumors. The loss of the tumor suppressor gene on chromosome 11q12-13 was involved in the formation of two pituitary adenomas, two pancreatic endocrine functioning tumors, and a parathyroid hyperplasia in this patient, but the tumorigenic factors in the specific endocrine organs remain to be studied.
掲載誌名
Endocrine Journal
ISSN
13484540
09188959
cat書誌ID
AA10901436
出版者
The Japan Endocrine Society
42
3
開始ページ
331
終了ページ
340
発行日
1995
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系
先端酵素学研究所