アクセス数 : ?
ダウンロード数 : ?
ID 114361
著者
Iwahana, Hiroyuki The University of Tokushima
Fukuda, Ayumi The University of Tokushima
Katsuragi, Kiyonori Otsuka Assay Laboratories
Kinoshita, Moritoshi Otsuka Assay Laboratories
齋藤, 史郎 The University of Tokushima
キーワード
ras Gene
Missense mutation
Thyroid follicular adenoma
Pheochromocytoma
資料タイプ
学術雑誌論文
抄録
To elucidate the molecular basis for endocrine tumorigenesis, ras mutations in human endocrine tumors were analyzed using polymerase chain reaction‐single strand conformation polymorphism (PCR‐SSCP) analysis. Mutations of the H‐, K‐, N‐ras genes were examined in genomic DNAs from 169 successfully amplified primary endocrine tumors out of 189 samples. Four out of 24 thyroid follicular adenomas analyzed contained mutated N‐ras codon 61, and one contained the mutated H‐ras codon 61. One of the 19 pheochromocytomas revealed mutation of the H‐ras codon 13. No mutations of the ras gene were detected in pituitary adenomas, parathyroid tumors, thyroid cancers, endocrine pancreatic tumors, and adrenocortical tumors. Based on these findings we conclude that activation of the ras gene may play a role in the tumorigenesis of a limited number of thyroid follicular adenomas and pheochromocytomas, and that mutation of the ras gene is not frequent in other human endocrine tumors.
掲載誌名
Japanese Journal of Cancer Research
cat書誌ID
AA00690844
出版者
Japanese Cancer Association|John Wiley & Sons
83
10
開始ページ
1057
終了ページ
1062
発行日
1992-10
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系
先端酵素学研究所