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ダウンロード数 : ?
ID 110646
著者
ホリ, アユコ Department of Radiology, The University of Tokushima School of Medicine
原田, 雅史 Department of Radiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
西谷, 弘 Department of Radiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宇野, 昌明 Department of Neurosurgery, The University of Tokushima School of Medicine
キーワード
99mTc-ECD
brain perfusion SPECT
acetazolamide
cerebral blood flow reserve
資料タイプ
学術雑誌論文
抄録
A technique for measuring the resting and acetazolamide (Acz)-activated cerebral blood flow without blood sampling by consecutive single-photon emission computed tomography (SPECT) using technetium-99m-L, L-ethyl cysteinate dimer (99mTc-ECD), called the 99mTc-ECD-RVR method, was recently developed by Matsuda et al . and Takeuchi et al . We evaluated the cerebral blood flow reserve in 77 patients with cerebrovascular diseases and 24 controls using this method. Baseline mean CBF (mCBF)was calculated from the application of Patlak plot graphical analysis with radionuclide angiography, and quantitative regional CBF (rCBF) images were obtained from qualitative axial SPECT images by the mCBF and Lassen’s linearization correction. The activated SPECT images were obtained by subtraction of the first image from the second image. The mean increment ratio (IR) by calculating the mean CBF for the pre- and post-Acz in the controls was 1.26±0.12 (mean±SD). In patients with cerebrovascular disease, the reduction of the mean IR and regional IR was parallel with the degree of stenosis. This noninvasive method was also considered to be useful in evaluating the change in the hemodynamic reserve in cerebrovascular disease.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
49
3-4
開始ページ
134
終了ページ
141
並び順
134
発行日
2002
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系