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ダウンロード数 : ?
ID 110818
著者
コガメ, マサヒロ Institute for Enzyme Research, The University of Tokushima|Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School
松尾, 伸二 Institute for Enzyme Research, The University of Tokushima KAKEN研究者をさがす
ナカタニ, マサシ Institute for Enzyme Research, The University of Tokushima
クリサキ, アキラ Institute for Enzyme Research, The University of Tokushima
西谷, 弘 Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ツチダ, クニヒロ Institute for Enzyme Research, The University of Tokushima
スギノ, ヒロム Institute for Enzyme Research, The University of Tokushima
キーワード
ALK7
adipocyte differentiation
activin
adipogenesis
TGF-beta
資料タイプ
学術雑誌論文
抄録
Transforming growth factor-β (TGF-β) family members regulate a variety of cellular functions and play important roles in cell differentiation. Activin receptor-like kinase 7 (ALK7), a receptor for TGF-β family members, was initially cloned from rats as an orphan receptor and has been recently shown to be a type I receptor for nodal, activin B and activin AB. ALK7 is expressed not only in neurons, but also in insulin-producing islet β cells and white and brown adipose tissues however, the specific functions of ALK7 in these tissues are not known. In order to test whether ALK7 is involved in adipocyte differentiation, we analyzed its expression during adipocyte differentiation. ALK7 expression was detected in the late phase of adipocyte differentiation by reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting and immunofluorescence staining in 3T3-L1 cells. We also detected the expression of ALK7 by RT-PCR in stromal vascular fraction (SVF) cells. These results indicated that ALK7 is a novel marker specifically expressed during the late phase of adipocyte differentiation. Furthermore, our results suggest the possible involvement of nodal or activin B in adipocyte differentiation.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
3-4
開始ページ
238
終了ページ
245
並び順
238
発行日
2006-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系