NIRS during cognitive tasks might predict drug response in OCD
武田, 知也 Tokushima University
住谷, さつき Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Hamatani, Sayo Tokushima University
Yokose, Yosuke Taoka Higashi Hospital
Shikata, Megumi Ibogawa Hospital
大森, 哲郎 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
verbal fluency test
Objective: We investigated oxyhemoglobin change in the prefrontal cortex (PFC) of patients with obsessive–compulsive disorder (OCD) who showed different responses to pharmacotherapy during neuropsychological tasks with near-infrared spectroscopy.
Subjects and methods: A total of 42 patients with OCD (mean age: 35.6±9.6 years, 14 men, 28 women) and healthy control subjects (mean age: 35.4±9.7 years, 13 men, 29 women) were selected. Patients with OCD were divided into three groups (responders to selective serotonin-reuptake inhibitors (SSRIs), responders to SSRIs with antipsychotics, and nonresponders to SSRIs and SSRIs with antipsychotics) based on pharmacological response. We investigated oxyhemoglobin change in the PFC of subjects during Stroop tasks and a verbal fluency test with near-infrared spectroscopy.
Results: Responders to SSRIs showed smaller activation compared to control subjects during the Stroop incongruent task and verbal fluency test, but not during the Stroop congruent task. In contrast, responders to SSRIs with antipsychotics showed smaller activation compared to control subjects during all three tasks.
Conclusion: Our results suggest that activation of the PFC during Stroop tasks might predict responses to pharmacotherapy of patients with OCD.
Neuropsychiatric Disease and Treatment
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