Takiguchi, Kazuo Tokyo Medical and Dental University|Haryugaoka Hospital
Uezato, Akihito Tokyo Medical and Dental University
Itasaka, Michio Tokyo Medical and Dental University
Atsuta, Hidenori Tokyo Medical and Dental University
Narushima, Kenji Tokyo Medical and Dental University
Yamamoto, Naoki Tokyo Medical and Dental University|Tokyo Metropolitan Tama Medical Center
Kurumaji, Akeo Tokyo Medical and Dental University
Tomita, Makoto Tokyo Medical and Dental University
Oshima, Kazunari Tokyo Medical and Dental University|Ohmiya Kousei Hospital
Shoda, Kosaku Ohmiya Kousei Hospital
Tamaru, Mai Tokushima University
Okazaki, Mitsutoshi National Center Hospital of Neurology and Psychiatry
Ishiwata, Sayuri Tokyo Medical and Dental University
Ishiwata, Yasuyoshi Tokyo Medical and Dental University
Yasuhara, Masato Tokyo Medical and Dental University
Arima, Kunimasa National Center Hospital of Neurology and Psychiatry
Nishikawa, Toru Tokyo Medical and Dental University
MR diffusion tensor imaging
Background: It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs.
Methods: We performed a placebo-controlled double-blind crossover study involving 41 schizophrenia patients in which D-cycloserine 50 mg/day was added-on, and the influence of the onset age and association with white matter integrity on MR diffusion tensor imaging were investigated for the first time. The patients were evaluated using the Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Brief Assessment of Cognition in Schizophrenia (BACS), and other scales.
Results: D-cycloserine did not improve positive or negative symptoms or cognitive dysfunction in schizophrenia. The investigation in consideration of the onset age suggests that D-cycloserine may aggravate negative symptoms of early-onset schizophrenia. The better treatment effect of D-cycloserine on BACS was observed when the white matter integrity of the sagittal stratum/ cingulum/fornix stria terminalis/genu of corpus callosum/external capsule was higher, and the better treatment effect on PANSS general psychopathology (PANSS-G) was observed when the white matter integrity of the splenium of corpus callosum was higher. In contrast, the better treatment effect of D-cycloserine on PANSS-G and SANS-IV were observed when the white matter integrity of the posterior thalamic radiation (left) was lower.
Conclusion: It was suggested that response to D-cycloserine is influenced by the onset age and white matter integrity.
BioMed Central|Springer Nature
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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