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ID 114908
タイトル別表記
Clozapine Pharmacogenetic Studies in Schizophrenia
著者
Hashimoto, Ryota Osaka University|National Center of Neurology and Psychiatry
キーワード
clozapine
schizophrenia
clinical response
agranulocytosis
pharmacogenetics
SNP
GWAS
review
資料タイプ
学術雑誌論文
抄録
Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia. Clinical response and appearance of adverse events vary among individual patients receiving clozapine, with genetic and non-genetic factors potentially contributing to individual variabilities. Pharmacogenetic studies investigate associations between genetic variants and drug efficacy and toxicity. To date, most pharmacogenetic studies of clozapine have been conducted through candidate gene approaches. A recent advance in technology made it possible to perform comprehensive genetic mapping underlying clinical phenotypes and outcomes, which allow novel findings beyond biological hypotheses based on current knowledge. In this paper, we will summarize the studies on clozapine pharmacogenetics that have extensively examined clinical response and agranulocytosis. While there is still limited evidence on clozapine efficacy, recent genome-wide studies provide further evidence of the involvement of the human leukocyte antigen (HLA) region in clozapine-induced agranulocytosis.
掲載誌名
Frontiers in Pharmacology
ISSN
16639812
出版者
Frontiers Media S.A.
9
開始ページ
1049
発行日
2018-9-26
権利情報
© 2018 Numata, Umehara, Ohmori and Hashimoto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院