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ID 114922
タイトル別表記
TREM2 Expression in Schizophrenia
著者
Mori, Yoko Ehime University
Yoshino, Yuta Ehime University
Ochi, Shinichiro Ehime University
Yamazaki, Kiyohiro Ehime University
Kawabe, Kentaro Ehime University
Abe, Masao Ehime University
Kitano, Tomoji Ehime University
Ozaki, Yuki Ehime University
Yoshida, Taku Ehime University
Mori, Takaaki Ehime University
Kuroda, Norio Kuroda Hospital
上野, 修一 Ehime University
資料タイプ
学術雑誌論文
抄録
TREM2 and TYROBP are causal genes for Nasu–Hakola disease (NHD), a rare autosomal recessive disease characterized by bone lesions and early-onset progressive dementia. TREM2 forms a receptor signaling complex with TYROBP, which triggers the activation of immune responses in macrophages and dendritic cells, and the functional polymorphism of TREM2 is reported to be associated with neurodegenerative disorders such as Alzheimer’s disease (AD). The objective of this study was to reveal the involvement of TYROBP and TREM2 in the pathophysiology of AD and schizophrenia. Methods: We investigated the mRNA expression level of the 2 genes in leukocytes of 26 patients with AD and 24 with schizophrenia in comparison with age-matched controls. Moreover, we performed gene association analysis between these 2 genes and schizophrenia. Results: No differences were found in TYROBP mRNA expression in patients with AD and schizophrenia; however, TREM2 mRNA expression was increased in patients with AD and schizophrenia compared with controls (P < 0.001). There were no genetic associations of either gene with schizophrenia in Japanese patients. Conclusion: TREM2 expression in leukocytes is elevated not only in AD but also in schizophrenia. Inflammatory processes involving TREM2 may occur in schizophrenia, as observed in neurocognitive disorders such as AD. TREM2 expression in leukocytes may be a novel biomarker for neurological and psychiatric disorders.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
10
9
開始ページ
e0136835
発行日
2015-09-02
権利情報
© 2015 Mori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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言語
eng
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出版社版
部局
医学系