ID 110726
著者
ササキ, カツヤ Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
ミヤケ, ヒデノリ Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
キノシタ, タカフミ Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
イケヤマ, シズオ Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
田代, 征記 Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
キーワード
ischemia-reperfusion injury
non-heart-beating donor
orthotopic liver transplantation
FK 506
OKY046
資料タイプ
学術雑誌論文
抄録
The study investigated the possibility of pharmacologically modulating hepatic allograft function from non-heart-beating donors (NHBDs)using male Lewisrats. The donors were divided into 4 groups :Group 1 in which the vehicle was administered, Group 2 in which FK506 (tacrolimus a powerful immunosuppressive agent)was administered,Group3 in which OKY046 (a specific thromboxane synthetase inhibitor) was administered and Group 4 in which FK506 and OKY046 were administered. The recipients received orthotopic liver transplantation. The survival rates differed significantly between the recipients that had received liver transplantation from Groups1 and 4. The serum liver enzyme and inflammatory cytokine concentrations of the recipients which had received liver transplantation from Groups 2, 3 and 4 were significantly lower than those of the recipients that had received liver transplantation from Group1. Although there was no significant difference, all parameters were better in the recipients that had received transplantation from Group 4 than those that had received transplantation from Groups 2 and 3. The action mechanisms of FK506 and OKY046 are completely different. Therefore, concomitant use of FK506 and OKY046 might have additive effects on liver transplantation from NHBDs. In conclusion, we demonstrated that pretreatment of NHBDs using FK506 and OKY 046 ameliorated graft viability.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
51
1-2
開始ページ
76
終了ページ
83
並び順
76
発行日
2004-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系