ID 110740
著者
佐藤, 宏彦 Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
ハラダ, マサミツ Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
田代, 征記 Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
シロヤ, ツトム Ono Pharmaceutical Co., Ltd.
イマワカ, ハルオ Ono Pharmaceutical Co., Ltd.
マチイ, コウジ Ono Pharmaceutical Co., Ltd.
キーワード
severe acute pancreatitis
Gabexate Mesilate
continuous arterial infusion therapy
資料タイプ
学術雑誌論文
抄録
The effectiveness of continuous arterial infusion of Gabexate Mesilate (FOY-007) on experimental acute pancreatitis was investigated. Acute necrotizing pancreatitis was induced by an injection of 10% Na-taurocholate (1ml/kg) into the main pancreatic duct of mongrel dogs. Animals were divided into three groups Group A: non-treated control, Group B: after the induction of pancreatitis, injected with FOY-007 intravenously (5mg/kg/hr), Group C: after the induction of pancreatitis, injectedwithFOY-007 via the celiac artery. The changes in the values of amylase and lipase in serum and ascites etc. were examined. A histological examination was done and the FOY-007 concentration of the pancreas was measured. In both groups B and C, the serum levels of amylase and lipase reached significantly to low levels compared with those in group A. The extents of pancreatic parenchyma necrosis in each group were 36.1, 25.3 and 19.5% , respectively, and were significantly improved in group C. In addition, theFOY-007levels in pancreas specimens in the intraarterial infusion group exceeded those in the intravenous infusion group by 32 times. The results suggest that continuous FOY-007 arterial infusion therapy is useful as a local treatment for severe acute pancreatitis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
51
3-4
開始ページ
186
終了ページ
193
並び順
186
発行日
2004-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系