ID 111274
タイトル別表記
進行頭頸部癌に対して化学放射線療法中の患者において経皮内視鏡的胃瘻造設術が治療中断や栄養状態に及ぼす効果
Efficacy of PEG on head and neck cancer
著者
合田, 正和 徳島大学大学院医科学教育部(医学専攻) KAKEN研究者をさがす
陣内, 自治 University of Tokushima
高岡, 司 University of Tokushima
古北, 由仁 University of Tokushima
キーワード
percutaneous endoscopic gastrostomy
PEG
nutritional support
chemoradiotherapy
head and neck cancer
資料タイプ
学位論文
抄録
Objective : Efficacy of percutaneous endoscopic gastrostomy (PEG) on unplanned treatment interruption and nutritional status was examined in patients undergoing chemoradiotherapy (CRT) for advanced head and neck cancer. Methods :We retrospectively reviewed hospital charts of 44 patients with advanced head and neck cancer who were treated with CRT. Results : CRT-induced mucositis of grade 3 or worse and inadequate oral intake of less than one third of their usual intake developed in 33 patients who were recommended PEG placement, but not in 11 patients. Thirteen patients accepted PEG placement and then completed CRT (compliant group). However, among 20 patients who refused both PEG and nasogastoric tube (NGT) placements (non-compliant group), 10 required unplanned interruptions of CRT at a radiation dose around 30-40 Gy (UI-CRT group) while 10 others could complete CRT without interruption (C-CRT group) CRT. Total serum protein levels were significantly decreased after CRT in all patients. Discussion : It is suggested that therapeutic PEG placement is useful for preventing unplanned interruption of CRT in patients with advanced head and neck cancer. After severe mucositis and inadequate oral intake have developed during CRT, PEG placement should be considered before the radiation therapy dose of 30 Gy.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
3-4
開始ページ
173
終了ページ
176
並び順
173
発行日
2015-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201508041003.pdf
論文本文 : LID201510261013.pdf
本論文は,著者Masakazu Godaの学位論文として提出され,学位審査・授与の対象となっている。
著者表記誤記あり(誤)Koich Tamura→(正) Koichi Tamura
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2864号
学位記番号
甲医第1253号
学位授与年月日
2015-07-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院