直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 83807
著者
Lin, Chun-Xing Second Department of Surgery, The University of Tokushima School of Medicine
門田, 康正 Second Department of Surgery, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
ウメモト, アツシ Second Department of Surgery, The University of Tokushima School of Medicine
キーワード
IQ
DNA adduct
colon
32P-postlabeling
metabolism
資料タイプ
学術雑誌論文
抄録
A food-born carcinogen, 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) induces cancer in the rat colon. The mechanism for colonic DNA adduct formation leading to cancer by IQ was studied using a colostomized F344 rat model. In this model, the transverse colon of the rat was colostomized, which produced a fecal stream-positive proximal colon and a negative distal colon were produced. When IQ (50 mg/kg) was administered into the distal colon of the colostomized rats (n=5), the ratio of the DNA adduct level of the distal colonic mucosa to the paired muscular layer 24 hr after dosage was 2.02, whereas that was 1.51 and 1.37 when IQ was administered into the stomach (n=6) and the vein (n=5), respectively. This suggested that luminal exposure of IQ induced DNA adduct formation. Since IQ (an amine form) has no reactivity toward DNA, these findings suggested that IQ was immediately activated in the absorbed mucosal cells and reacted with DNA. However, most of the IQ absorbed was metabolically activated in the liver, distributed by blood circulation, and formed DNA adducts in the colonic mucosa and muscular layer.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
1-2
開始ページ
102
終了ページ
108
並び順
102
発行日
2001
備考
フルテキストファイル
言語
eng
部局
医学系