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ID 117621
タイトル別表記
LPA, C1P, and S1P in IPF
著者
Takahashi, Naoko Tokushima University
Morito, Katsuya Tokushima University
Ali, Hanif Tokushima University
香川, 耕造 Tokushima University
Hasi, Rumana Yesmin Tokushima University
キーワード
idiopathic pulmonary fibrosis
ceramide 1-phosphate
lysophosphatidic acid
sphingosine 1-phosphate
liquid chromatography-tandem mass spectrometry
資料タイプ
学術雑誌論文
抄録
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonias. Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are signaling lipids that evoke growth factor-like responses to many cells. Recent studies revealed the involvement of LPA and S1P in the pathology of IPF. In this study, we determined LPA, S1P and ceramide 1-phosphate (C1P) in peripheral blood plasma of IPF patients, and examined correlation to the vital capacity of lung (VC), an indicator of development of fibrosis. Blood plasma samples were taken from eleven patients with IPF and seven healthy volunteers. The lipids of the sample were extracted and subjected to liquid chromatography-tandem mass spectrometry for analysis. Results showed that there is a significant negative correlation between VC and plasma LPA levels, indicating that IPF patients with advanced fibrosis had higher concentration of LPA in their plasma. Average of S1P levels were significantly higher in IPF patients than those in healthy subjects. Although it is not statistically significant, a similar correlation trend that observed in LPA levels also found between VC and S1P levels. These results indicated that plasma LPA and S1P may be associated with deterioration of pulmonary function of IPF patients.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
出版者
Tokushima University Faculty of Medicine
69
3-4
開始ページ
196
終了ページ
203
並び順
196
発行日
2022-08
備考
著者英表記誤記あり (誤)Rumana Yesmin Has →(正)Rumana Yesmin Hasi
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
病院
医学系
生物資源系