アクセス数 : ?
ダウンロード数 : ?
ID 83803
著者
金山, 博臣 Department of Urology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
matrix metalloproteinase
tumor invasion
metastasis
progression
bladder cancer
資料タイプ
学術雑誌論文
抄録
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes which degrade the extracellular matrix or components of the basement membrane. They have essential roles in tumor invasion and metastasis. In bladder cancer, elevated MMP-2 and MMP-9 expression in tumor tissues, correlated with tumor stage, grade or prognosis, were reported in several studies. Moreover, high levels of serum or urine MMP and TIMP were observed in patients with bladder cancer especially in advanced cases. However, the true roles of MMPs and TIMPs in bladder cancer progression are not yet clarified. Here, we discuss the roles and clinical implications of MMPs in bladder cancer.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
1-2
開始ページ
31
終了ページ
43
並び順
31
発行日
2001
備考
フルテキストファイル
言語
eng
部局
医学系