ID 111271
タイトル別表記
浸潤性子宮頸癌における血管内皮増殖因子の発現と微小血管密度の重要性について
著者
西條, 康代 徳島大学大学院医学研究科(外科系専攻)
古本, 博孝 The University of Tokushima|Tokushima Red Cross Hospital KAKEN研究者をさがす
キーワード
cervical cancer
vascular endothelial growth factor
microvessel density
bevacizumab
angiogenesis
資料タイプ
学位論文
抄録
To determine whether vascular endothelial growth factor (VEGF) expression and microvessel density are predictive of prognosis in cases of invasive cervical cancer, correlations among VEGF expression, microvessel density, and clinicopathological parameters were identified. VEGF expression was evaluated in 50 cervical cancer samples by immunohistochemical staining. Microvessel density was assessed by immunostaining for CD31-positive endothelial cells in the most vascularized areas of tumors. VEGF expression and microvessel density were significantly higher in adenocarcinomas than in squamous cell carcinomas. However, in cases of adenocarcinoma, no significant correlations were found among VEGF expression, microvessel density, and clinicopathological parameters. In contrast, for squamous cell carcinomas, microvessel density was significantly higher in cases at an advanced stage and in those with several other poor prognostic factors. The finding that cervical adenocarcinomas exhibited greater VEGF expression and microvessel density than squamous cell carcinomas may explain the poorer prognosis of adenocarcinoma compared with squamous cell carcinoma. Moreover, microvessel density in squamous cell carcinomas was significantly correlated with poor prognostic factors. Therefore, there is possibility that bevacizumab, a humanized monoclonal antibody against VEGF-A, may be useful in the initial treatment targeting angiogenesis for early-stage cervical cancer.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
3-4
開始ページ
154
終了ページ
160
並び順
154
発行日
2015-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201505211003.pdf
論文本文 : LID201505211004.pdf
本論文は,著者Yasuyo Saijoの学位論文として提出され,学位審査・授与の対象となっている。
西條康代の姓「西」の正確な漢字については審査要旨をご参照ください。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2800号
学位記番号
甲医第1242号
学位授与年月日
2015-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系