ID 111649
著者
古本, 博孝 The University of Tokushima KAKEN研究者をさがす
Kamada, Masaharu The University of Tokushima
Katsura, Masumi The University of Tokushima
Aono, Toshihiro The University of Tokushima
キーワード
ATL
triple malignancies
IL-2
IL-2 inhibitor
資料タイプ
学術雑誌論文
抄録
A patient with triple malignancies is reported, who presented cervical cancer, vulvar cancer and adult T cell leukemia (ATL). ATL was diagnosed as a smouldering type, because antibody to human T cell leukemia virus associated antigen (ATLA) was positive with a titer of 1 : 160. Although her malignant cells had an OKT 4+8-3+Tac+ phenotype, the cells did not display helper T cell functions. Namely they showed no response to Phytohemagglutinin (PHA) and Interleukin 2 (IL-2) and suppressed the PWM driven IgG synthesis of B cells obtained from healthy donor. They did not produce IL-2 by stimulation with PHA and phorbol myristate acetate (PMA). Furthermore, these ATL cells were producing IL-2 inhibitor like factors. As synchronous triple malignancies are extremely rare, two gynecologic cancers seem to ascribe to the suppressing state of the immunosurveillance mechanism by viral infection.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
The University of Tokushima School of Medicine
44
1-2
開始ページ
99
終了ページ
102
並び順
99
発行日
1997-08
EDB ID
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院