ID 113613
タイトル別表記
Human papillomavirus in maternal milk
著者
古本, 博孝 The University of Tokushima KAKEN研究者をさがす
前田, 和寿 The University of Tokushima KAKEN研究者をさがす
キーワード
HPV
maternal milk
transmission
資料タイプ
学術雑誌論文
抄録
Objective: Human papillomavirus (HPV) DNA has been detected in the oral cavity of infants and breast cancer tissue, suggesting its vertical transmission through maternal milk. We determined whether HPV is detected in maternal milk and is vertically transmitted by breast feefing.
Methods: Informed consent was obtained, and maternal milk samples (n = 80) were analyzed for high-risk HPV DNA. In 43 women, this DNA was measured in the uterine cervix. In women with positive samples, this DNA was measured in the oral cavities of their children. The domain including HPV E6 and E7 was amplified by polymerase chain reaction using consensus primers, and HPV serotype determined by electrophoresis after restriction enzyme digestion.
Results: High-risk HPV-16 was detected in 2 of 80 samples (2.5%), and in these 2 cases, high-risk HPV was not detected in the uterine cervix or oral cavity of the child.
Conclusion: The infection of HPV in maternal milk is rare (2/80), vertical transmission through maternal milk was not detected in this study (0/80). HPV infection through maternal milk may occur, but its likelihood is low.
掲載誌名
Journal of Obstetrics and Gynaecology
ISSN
01443615
13646893
cat書誌ID
AA0025872X
出版者
Taylor & Francis
31
6
開始ページ
503
終了ページ
506
発行日
2011-08-08
備考
Figure なし
権利情報
This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Obstetrics and Gynaecology on 08/08/2011, available online: http://www.tandfonline.com/10.3109/01443615.2011.570814.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
病院
医学系