ID 110670
著者
尾崎, 修治 First Department of Internal Medicine, The University of Tokushima School of Medicine
オガサハラ, コウジ First Department of Internal Medicine, The University of Tokushima School of Medicine
コサカ, マサアキ First Department of Internal Medicine, The University of Tokushima School of Medicine
Inoshita, Toshi First Department of Internal Medicine, The University of Tokushima School of Medicine
ワカツキ, シンゴ First Department of Pathology, The University of Tokushima School of Medicine
上原, 久典 Second Department of Pathology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
松本, 俊夫 First Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
hepatosplenic lymphoma
γδT-cell
hepatitis B virus
chronic hepatitis
hepatosplenomegaly
資料タイプ
学術雑誌論文
抄録
Hepatitis B virus (HBV) infection has been implicated in the development of hepatocellular and hematopoietic malignancies. We describe a patient with chronic hepatitis B who developed hepatosplenic γδT-cell lymphoma. A 45-year-old woman presented with marked hepatosplenomegaly and hepatic failure during the course of chronic hepatitis B. Peripheral blood examination revealed57% abnormal lymphoid cells which expressed the γδT-cell receptor. The cytogenetic analysis of tumor cells showed an abnormal karyotype 47, XX, -13, +2mar in all 20 metaphases examined. A clonal rearrangement of the T-cell receptor genes was demonstrated by Southern blot analysis, showing monoclonal expansion of tumor cells. A liver biopsy specimen showed fibrosis of the portal areas and sinusoidal infiltration of tumor cells. HBV infection was documented by the presence of IgG anti-HBc and anti-HBs antibodies in serum. Although HBV-DNA was not detected in tumor cells by polymerase chain reaction analysis, there is a possibility that proliferation of γδT cells in response to HBV infection played a role in the pathogenesis of hepatosplenic γδT-cell lymphoma.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
215
終了ページ
217
並び順
215
発行日
1998
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
先端酵素学研究所