ID 112987
タイトル別表記
De novo CD 20‐negative diffuse large B‐cell lymphoma developed with sustained fever and markedly high C‐reactive protein level
CD20陰性DLBCL
著者
宮上, 侑子 徳島大学
岡本, 惠暢 徳島大学
高橋, 真美子 徳島大学
岩佐, 昌美 徳島大学
キーワード
CD20
fever of unknown origin
diffuse large B-cell lymphoma
CRP
資料タイプ
学術雑誌論文
抄録
A 68-year-old woman presented with sustained fever for more than 1 month and admitted due to hematemesis and systemic edema. Computed tomography scan revealed swelling of the cervical, paraaortic lymph nodes. Blood test results showed severe anemia, elevation of white blood cell count, elevation of liver enzyme and coagulopathy with high C-reactive protein. Biopsy of the right cervical lymph node showed proliferation of abnormal lymphoid cells with necrosis and hemorrhage, which are positive for CD79α, CD30, MUM‐1, and bcl‐6 and negative for CD20, CD5, CD10, ALK, CD38, CD138, and EBER. Gene rearrangement of immunoglobulin heavy chain was detected in tumor cells. Bone marrow aspiration showed tumor involvement. The patient was diagnosed with de novo CD20‐negative diffuse large B-cell lymphoma(DLBCL)stage IV B. Reduced CHOP therapy was performed under artificial respiration due to pulmonary edema and takotsubo cardiomyopathy. Although her general condition and high CRP levels temporarily improved, she died 47 days after admission due to rapid relapse. De novo CD20‐negative DLBCL was rare and presented with high CRP levels and rapid progression, and was thought to be clinically different from the existing DLBCL. It is imperative to elucidate molecular pathophysiology and establish new treatment strategy for de novo CD20‐negative DLBCL.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
74
5-6
開始ページ
193
終了ページ
200
並び順
193
発行日
2018-12-25
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系
病院