ID 41811
タイトルヨミ
スイミン ト セイタイ リズム
タイトル別表記
Sleep and Biological Clock
著者
勢井, 宏義 徳島大学大学院ヘルスバイオサイエンス研究部神経情報医学部門情報統合医学講座統合生理学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
circadian
sleep
circadian-related genes
資料タイプ
学術雑誌論文
抄録
Circadian rhythm is an endogenous rhythm controlled by a master oscillator (biological clock) in the supra-chiasmatic nucleus (SCN), affecting on the almost all physiological functions including sleep/wake regulation. Recently the biological clock has been shown to function at the molecular level, and several circadian-related genes have been identified, such as the Clock, Per 1-3, Bmal 1 or Cry 1, 2.
We observed the sleep/wake rhythm in cry 1, 2 double knockout mice and clock mutant mice. Both strains have lost the circadian oscillation in the expression of circadian-related genes. Cry 1, 2 double knockout mice show the entrained sleep/wake rhythm to ordinary light-dark (LD) cycle, although they show completely flattened rhythm under the constant dark (DD) condition. On the other hand, clock mutant mice show the persistent circadian sleep/wake rhythm under even DD conditions. Although the expression of circadian-related genes do not oscillate, the clock mutant mice have potent circadian rhythm in body core temperature, behavior, sleep/wake and cortisol etc. The clock mutant mice have a longer (27 hrs) period of free-running rhythm under DD condition, and the phase of sleep/wake rhythm is delayed for about two hours comparing to the wild-type under LD condition.
The important role of the circadian-related genes in the sleep/wake regulation has been indicated. The functional impairment of the circadian-related genes may be involved in the sleep disorders, such as insomnia or hypersomnia.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
60
1-2
開始ページ
8
終了ページ
13
並び順
8
発行日
2004-05-25
備考
EDB ID
フルテキストファイル
言語
jpn
部局
医学系