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ID 115811
著者
岩橋, 衆一 The University of Tokushima KAKEN研究者をさがす
宇都宮, 徹 The University of Tokushima KAKEN研究者をさがす
花岡, 潤 The University of Tokushima
キーワード
Cholangiolocellular carcinoma
Hepatic stem cells
Combined hepatocellular cholangiocarcinoma
Cancer stem cell marker
資料タイプ
学術雑誌論文
抄録
Purpose
Cholangiolocellular carcinoma (CLC) is an extremely rare malignant liver tumor. It is thought to originate from the ductules and/or canals of Hering, where hepatic stem cells (HpSC) are located, but there are few reports on cancer stem cell markers in CLC. Thus, we evaluated the significance of cancer stem cell markers, including CD133, CD44, and EpCAM, in CLC.
Methods
The subjects of this study were three patients with CLC and one patient with an intermediate type of combined hepatocellular cholangiocarcinoma (CHC). The cancer cell markers, CK7, CK19, and EMA, were evaluated immunohistochemically.
Results
Histological examination of the CLC revealed morphologically cholangiolar features and immunohistochemical examination revealed positivity for CD133, CD44, and EpCAM. On the other hand, in the intermediate type of CHC, only CD44 was positive, whereas CD133 and EpCAM were negative.
Conclusion
CLC may have stronger features derived from HpSCs than an intermediate type of CHC.
掲載誌名
Surgery Today
ISSN
09411291
14362813
cat書誌ID
AA10824685
出版者
Japan Surgical Society|Springer
43
6
開始ページ
654
終了ページ
660
発行日
2012-11-29
権利情報
This article is distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系