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ID 114060
タイトル別表記
Refeeding Hypophosphatemia in Anorexia Nervosa
著者
Tamaru, Mai University of Tokushima
キーワード
hypophosphatemia
refeeding
anorexia nervosa
risk factor
inpatients
資料タイプ
学術雑誌論文
抄録
Objective: Refeeding in patients with anorexia nervosa (AN) is associated with a risk of refeeding syndrome (RS), which is a disruption in metabolism with a variety of features including hypophosphatemia. We evaluated the risk factors for refeeding hypophosphatemia (RH) during nutritional replenishment in Japanese patients with AN. Methods: We retrospectively examined clinical data for 99 female inpatients (mean age 30.9 ± 10.7 years, range: 9 to 56 years). Results: RH (phosphate <2.3 mg/dL) occurred within 4.8 ± 3.7 days of hospital admission and was still observed at 28 days after admission in 21 of the 99 cases (21.2%). Oral or intravenous phosphate was given to some patients to treat or prevent RH. Patients with RH had a significantly lower body mass index, were older, and had higher blood urea nitrogen than those without RH. Severe complications associated with RH were recorded in only one patient who showed convulsions and disturbed consciousness at day 3 when her serum phosphate level was 1.6 mg/dL. Conclusion: The significant risk factors for RH that we identified were lower BMI, older age, and higher blood urea nitrogen at admission. No significant difference in total energy intake was seen between the RH and no RH groups, suggesting that RH may not be entirely correlated with energy intake. Precisely predicting and preventing RH is difficult, even in patients with AN who are given phosphate for prophylaxis. Thus, serum phosphate levels should be monitored for at least 5-10 days after admission.
掲載誌名
International Journal of Eating Disorders
ISSN
1098108X
出版者
Wiley Periodicals
49
4
開始ページ
402
終了ページ
406
発行日
2015-10-08
備考
This is the peer reviewed version of the following article: Kameoka, N. , Iga, J. , Tamaru, M. , Tominaga, T. , Kubo, H. , Watanabe, S. , Sumitani, S. , Tomotake, M. and Ohmori, T. (2016), Risk factors for refeeding hypophosphatemia in Japanese inpatients with anorexia nervosa. Int. J. Eat. Disord., 49: 402-406., which has been published in final form at https://doi.org/10.1002/eat.22472. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
病院
医学系
特別修学支援室