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ダウンロード数 : ?
ID 83815
著者
カワハラ, ツカサ Department of Nutritional Physiology, The University of Tokushima School of Medicine
桑野, 由紀 Department of Nutritional Physiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
近藤(手嶋), 茂忠 Department of Nutritional Physiology, The University of Tokushima School of Medicine KAKEN研究者をさがす
スギヤマ, トシロウ Third Department of Internal Medicine, Hokkaido University School of Medicine
カワイ, トモコ Department of Nutritional Physiology, The University of Tokushima School of Medicine
二川, 健 Department of Nutritional Physiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岸, 恭一 Department of Nutritional Physiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
六反, 一仁 Department of Nutritional Physiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
apoptosis
Helicobacter pylori
cag PAI gene
LPS
gastric mucosal cells
資料タイプ
学術雑誌論文
抄録
The cag pathogenicity island (cag PAI) genes are a major determinant of virulence of Helicobacter pylori (Hp). Lipopolysaccharide (LPS) purified from the cag PAI-positive (type I) strains induced apoptosis of primary cultures of guinea pig gastric mucosal cells. Lipid A catalyzed this apoptosis. These cells expressed the Toll-like receptor 4 (TLR4) mRNA and its protein, and type I Hp LPS phosphorylated transforming growth factor β-activated kinase 1 (TAK1) and TAK1-binding protein 1 (TAB1) in association with up-regulation of the TLR4 expressions, suggesting that type I Hp LPS evoked distinct TLR4 signaling. In contrast, Hp LPS from type II strains with complete or partial deletion of the cag PAI genes did not phosphorylate TAK1 and TAB1 and failed to induce apoptosis. Accelerated apoptosis of gastric epithelial cells is one of the important events relevant to chronic, atrophic gastritis caused by Hp infection. The difference in proapoptotic action of LPS between the type I and II strains may support an important role of the cag PAI genes in the pathogenesis of gastric lesions caused by Hp infection.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
48
3-4
開始ページ
166
終了ページ
174
並び順
166
発行日
2001
備考
EDB ID
フルテキストファイル
言語
eng
部局
医学系