アクセス数 : ?
ダウンロード数 : ?
ID 110667
著者
山中, 仙示 Department of Clinical Nutrition, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
武田, 英二 Department of Clinical Nutrition, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
高田, 和美 Department of Clinical Nutrition, The University of Tokushima School of Medicine
首藤, 恵泉 Department of Clinical Nutrition, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
宮本, 賢一 Department of Clinical Nutrition, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ワタナベ, ツトム Department of Pediatrics, The University of Tokushima School of Medicine
カワノ, ヨシフミ Department of Pediatrics, The University of Tokushima School of Medicine
タカウエ, ヨウイチ Department of Pediatrics, The University of Tokushima School of Medicine
黒田, 泰弘 Department of Pediatrics, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
キーワード
total parenteral nutrition
peripheral blood stem cell transplantation
resting energy expenditure
respiratory quotient
nutritional support
資料タイプ
学術雑誌論文
抄録
The resting energy expenditure (REE) and the respiratory quotient (RQ) were measured longitudinally using indirect calorimetry to examine the effects of total parenteral nutrition (TPN) on energy metabolism in children undergoing autologous peripheral blood stem cell transplantation (PBSCT). There were six children (two males and four females) and the age ranged from five to 13 years (median, eight yrs.). The diagnosis included acute lymphocytic leukemia (ALL ; 4), neuroblastoma (NBL ; 1) and primitive neuroectodermal tumor (PNET ; 1). TPN was started after the patients were stabilized following PBSCT (group A ; n=3) or before the initiation of high-dose cytoreductive chemotherapy (HCC) (group B ; n=3). Duration of HCC before PBSCT was identical between the two groups (six to eight days). Average total calorie and protein intake during HCC was significantly higher for group B than for group A. The %REE, the percentage of REE to the predicted basal energy expenditure (BEE), in group A showed 133±19%, 129±14% and 146±11% during three periods of HCC (days -8 to -1 of PBSCT), bone marrow suppression (days 0 to 11 of PBSCT) and bone marrow recovery (days 12 to 22 of PBSCT), respectively. In contrast, those in group B were 10% to 20% lower than those in group A at all periods. Carbohydrate oxidation rates during HCC in group A were significantly lower than those in group B, and those were not different between both groups during post-PBSCT periods. Fat oxidation rates in both groups were similar at all stages of periods. In contrast, protein degradation rates in group A were significantly higher than those in group B at all stages of the period. From these results, we concluded that commencement of TPN administration prior to HCC in the patients undergoing PBSCT provides beneficial effects to maintain better energy metabolic and nutritional status.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
199
終了ページ
203
並び順
199
発行日
1998
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系