ID 110658
著者
六反, 一仁 Department of Nutritional Physiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ヒラカワ, テツヤ Department of Parasitology, The University of Tokushima School of Medicine
手嶋, 茂忠 Department of Nutritional Physiology, The University of Tokushima School of Medicine KAKEN研究者をさがす
ナカノ, ヨウコ Department of Biology, Tsukuba Laboratories for Drug Discovery, Eisai Co.
ミヨシ, マミ Department of Nutritional Physiology, The University of Tokushima School of Medicine
河合, 智子 Department of Nutritional Physiology, The University of Tokushima School of Medicine
コンダ, エミ Department of Nutritional Physiology, The University of Tokushima School of Medicine
モリナガ, ヒロコ Department of Nutritional Physiology, The University of Tokushima School of Medicine
二川, 健 Department of Nutritional Physiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
岸, 恭一 Department of Nutritional Physiology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
heat shock / stress proteins
physiologic stress
stress ulcer
ischemic tolerance
chaperone inducers
資料タイプ
学術雑誌論文
抄録
Heat shock/ stress proteins (HSPs) are crucial for maintenance of cellular homeostasis during normal cell growth and for survival during and after various cellular stresses. The HSP70 family functions as molecular chaperones and reduces stress-induced denaturation and aggregation of intracellular proteins. In addition to the chaperoning activities, HSP70 has been suggested to exert its protective action by protecting mitochondria and by interfering with the stress-induced apoptotic program. The biochemical and functional properties of HSPs observed in cultured cells may be relevant to organs and tissues in whole animals. The activation of the hypothalamic-pituitary-adrenal axis and the sympathetic nerve system elicits the stress response in selected peripheral tissues the HSP70 expression in the vasculature and stomach increases resistance against hemodynamic stress and stress-induced mucosal damage, respectively. Gastric mucosa pretreated with mild irritants acquires a tolerance against subsequent mucosal-damaging insults. This phenomenon is known as “adaptive cytoprotection”. Transient ischemia also induces ischemic tolerance in the brain and heart, which is called “ischemic preconditioning”. The heat shock response is believed to contribute to the acquisition of the tolerance. The therapeutic applications of chaperone inducers that induce HSPs without any toxic effect are also introduced.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
137
終了ページ
147
並び順
137
発行日
1998
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系