ID 111563
著者
Morita, Kyoko The University of Tokushima
Saito, Toshiro Hitachi, Ltd.
Ohta, Masayuki Hitachi, Ltd.
Ueno, Shu-ichi The University of Tokushima
キーワード
stress
depression
biological maker
DNA microarray
資料タイプ
学術雑誌論文
抄録
Precise assessment of stress is an imminent issue to deal with stress-related social, medical and psychological problems. Psychological stress is known to stimulate the neuroendocrine, sympathetic nervous, and immune systems. By analyzing mRNA expression levels in leukocytes, which express receptors for hormones, neurotransmitters, growth factors, cytokines, and other stress related signals, levels of stress may be adequately measured. In a series of studies, our group has developed a cDNA microarray specifically designed to measure the mRNA levels of stress-related genes in peripheral blood leukocytes. This microarray enabled us to sensitively detect the response to psychological stress. In addition, our preliminary study suggests that the array could differentiate patients with depression from sex- and age-matched control subjects.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
52
Supplement
開始ページ
266
終了ページ
271
並び順
266
発行日
2005-11
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系