ID 110769
著者
六反, 一仁 Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima|The Research Institute of Science and Technology for Science of Japan Science and Technology 徳島大学 教育研究者総覧 KAKEN研究者をさがす
モリタ, キョウコ Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima
増田, 清士 Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
トミナガ, クミコ Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School
シキシマ, ミチヨ The Research Institute of Science and Technology for Science of Japan Science and Technology
近藤, 茂忠 Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima KAKEN研究者をさがす
大森, 哲郎 Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima 徳島大学 教育研究者総覧 KAKEN研究者をさがす
セキヤマ, アツオ Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School
キーワード
stress
allostasis
hypothalamus-pituitary-adrenal axis
stress assessment
microarray
資料タイプ
学術雑誌論文
抄録
Stress is the coordinated physiological processes to maintain a dynamic equilibrium under stressful conditions. The equilibrium is threatened by certain physiological and psychological stressors. Stressors trigger physiological, behavioural, and metabolic responses that are aimed at reinstating homeostasis. The hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system play an essential role in the stress response. Excessive, prolonged, or inadequate response that is termed as “allostasis” or “allostatic load” leads to pathological outcomes. Dysregulation of the HPA axis activity is involved in the pathogenesis of stress related disorders including major depression. The complex brain-immune-endocrine network regulates the HPA axis, and hereditary predisposition as well as environmental factors such as traumatic experiences in early life also modifies the capacity of an individual to cope. Therefore, it is difficult to correctly assess the complex stress response. We have developed a microarray carrying 1,467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Using this tool, we have succeeded to objectively assess individual response to acute psychological stress and to detect unique expression profiles in patients with depression. Gene expression profile in peripheral blood leukocytes may be a potentially useful for the detection of disease-associated, abnormal stress responses.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
52
3-4
開始ページ
137
終了ページ
144
並び順
137
発行日
2005-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系