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ID 110822
著者
Piroozmand, Ahmad Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School
Khamsri, Boonruang Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School
フジタ, ミカコ Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School
足立, 昭夫 Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
内山, 恒夫 Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
キーワード
HIV-2
accessory proteins
Vpx
Vpr
資料タイプ
学術雑誌論文
抄録
We have previously shown that human immunodeficiency virus type 2 (HIV-2) without functional vpx and vpr genes is severely defective for viral growth in lymphocytic cells, and suggested that the virions produced in the absence of Vpx and Vpr are critically damaged. To examine the nature of replication-defect for the vpx/vpr double mutant, we quantitatively and morphologically studied the virions produced in cells transfected or infected with wild type clone, single (vpx and vpr mutants) or the double mutant. While no significant difference in virion production was found for various virus clones in transfected cells, a major growth retardation in infected cells was readily observed for the vpx and vpx/vpr mutants. In particular, no viral growth was detected for the double mutant. By contrast to the very distinct growth characteristics of the three mutant clones, no appreciable difference in virion morphology was noted. These results indicated that Vpx and Vpr of HIV-2 may cooperatively contribute to virion infectivity without affecting virion morphogenesis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
3-4
開始ページ
271
終了ページ
276
並び順
271
発行日
2006-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系