ID 72821
著者
ナガオ, タミコ Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
ヤマシタ, トモキ Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
三宅, 在子 Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
内山, 恒夫 Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
野間口, 雅子 Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
足立, 昭夫 Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
HIV-1
Vif
APOBEC3G
APOBEC3F
資料タイプ
学術雑誌論文
抄録
We examined a series of site-directed point mutants of human immunodeficiency virus type 1 (HIV-1) Vif for their interaction with cellular anti-viral factors APOBEC3G/APOBEC3F. Mutant viruses that display growth-defect in H9 cells did not counteract effectively APOBEC3G and/or APOBEC3F without exception, as monitored by single-cycle infectivity assays. While growth-defective mutants of Vif C-terminal region were unable to suppress APOBEC3G/APOBEC3F, some N-terminal region mutants did neutralize one of APOBEC3G/APOBEC3F. These data have suggested that members of APOBEC3 family other than APOBEC3G/APOBEC3F are not important for anti-HIV-1 activity. Furthermore, APOPEC3G/APOBEC3F were found to differently associate with Vif in virions as analyzed by equilibrium density centrifugation. Taken together, these results indicated that interaction of HIV-1 Vif and APOBEC3G is distinct from that between Vif and APOBEC3F.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
1-2
開始ページ
89
終了ページ
94
並び順
89
発行日
2010-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
フルテキストファイル
言語
eng
部局
医学系