ID 83261
著者
イイダ, シンヤ Department of Virology, The University of Tokushima School of Medicine
福森, 知治 Department of Virology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
オオシマ, ヨウコ Department of Virology, The University of Tokushima School of Medicine
コヤマ, ハジメ Department of Virology, The University of Tokushima School of Medicine
足立, 昭夫 Department of Virology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
HIV-1
Vpu
accessory gene
資料タイプ
学術雑誌論文
抄録
A mutant designated NL-E65, which lacks the expression of entire vpu gene, was constructed from T-cell tropic wild-type (wt) human immunodeficiency virus type1(HIV-1) clone and monitored for its replication property in human cells, along with a mutant NL-Ss which expresses a C-terminal truncated Vpu. The mutant NL-Ss could grow in two cell lines and in all peripheral blood mononuclear cell (PBMC) preparations to some extent, with kinetics similar to those of wt virus. Likewise, the mutant NL-E65exhibited a replication property typical to the vpu mutant in the two cell lines and in all PBMC cultures, growing at a low level. Along with the results previously reported, these data indicate that HIV-1 Vpu is dispensable for virus replication in any of the types of cells so far tested.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
46
1-2
開始ページ
43
終了ページ
47
並び順
43
発行日
1999
備考
EDB ID
フルテキストファイル
言語
eng
部局
病院
医学系