ID 106363
著者
ヒガシモト, ミノル Faculty of Pharmaceutical Sciences, Tokushima Bunri University|AWA Laboratory of Health-Food Drinks
イソヤマ, ナオヒロ Faculty of Pharmaceutical Sciences, Tokushima Bunri University
イシバシ, サトシ Faculty of Pharmaceutical Sciences, Tokushima Bunri University
オガワ, ナオコ Faculty of Human Life Sciences, Tokushima Bunri University
瀧口, 益史 Faculty of Pharmaceutical Sciences, Tokushima Bunri University|Faculty of Pharmaceutical Sciences, Hiroshima International University
スズキ, シンヤ Faculty of Pharmaceutical Sciences, Tokushima Bunri University
大西, 克成 Graduate School of Medicine, the University of Tokushima 徳島大学 教育研究者総覧
サトウ, マサオ Faculty of Pharmaceutical Sciences, Tokushima Bunri University
キーワード
metallothionein
repeated mild stress
DNA damage
dyslipidemia
資料タイプ
学術雑誌論文
抄録
The effects of repeated mild stress on DNA and lipid metabolic damages in multiple organs of dyslipidemic mice, and the preventive role of metallothionein (MT) were investigated. Female adult wild-type and MT-null mice fed high-fat diet (HFD) or standard diet (STD) were repeatedly subjected to fasting or restraint for three weeks. The liver, pancreas, spleen, bone marrow and serum samples were taken for evaluating DNA damage, MT, glutathione (GSH), corticosterone, carnitine and adiponectin. Body weights of restraint groups were reduced with the intensity of stress increased, even if the energy intakes were higher than those of STD group. Hepatic GSH levels were reduced in HFD control group and were further reduced in stress groups, especially in restraint groups, while the hepatic MT and serum corticosterone levels were increased in concert with the intensity of stress. Cellular DNA damages were generally increased by the restraint stress, especially in MT-null mice. Hepatic carnitine levels of MT-null mice were markedly lower than those of wild-type mice. The data suggest that MT plays a preventive role by acting as an antioxidant in corporation with GSH decreased by repeated stress and that MT may be an essential factor for inducing carnitine under the stress.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
3-4
開始ページ
240
終了ページ
248
並び順
240
発行日
2013-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系