ID 110558
タイトルヨミ
ジアエンソサンナトリウムエキ ノ ユウコウ リヨウ ニ カンスル ケントウ
タイトル別表記
Effective use of sodium hypochlorite solution acidified with acetic acid
著者
桑原, 知巳 徳島大学大学院医学研究科生体制御医学講座分子細菌学分野
黒岩, 希実子 徳島大学大学院医学研究科生体制御医学講座分子細菌学分野
中山, 治之 徳島大学大学院医学研究科生体制御医学講座分子細菌学分野
大西, 克成 徳島大学大学院医学研究科生体制御医学講座分子細菌学分野 徳島大学 教育研究者総覧
キーワード
sodium hypochlorite
acidification
bactericidal activity
acetic acid
spore
資料タイプ
その他
抄録
Sodium hypochlorite solution is cheap and powerful disinfectant widely used in hospitals and food industries. The bactericidal activity of chlorine solution is considered to depend on the amount of dissociated hypochlorite (HClO) in the solutions. The most important factor affecting the amount of HClO in the chroline solution is pH, and the decrease in pH increases the concentration of dissociated HClO. Alkaline solutions of both sodium and calcium hypochlorite contain only small amount (about 10% of free available chroline in these solution) of HClO. Recently, there are several reports showing the effectiveness of “acidic hypochlorite solution”, which is adjusted pH with hydrochloric acid (HCl) to 5.0, as a powerful disinfectant. However, special attention must be paid to handling and storage of HCl, and the increase of chlorine content in the solution by the addition of HCl might possibly induce toxic chlorine gas production. In this study, the bactericidal activity of acidic hypochlorite solutions, which have been adjusted to pH 5.0 with hydrochloric acid, acetic acid, citrate, lactate, formate, phosphate or sulphate, was investigated using various bacterial strains. The acidic hypochlorite solution prepared with acetic acid showed the equivalent bactericidal activity to that with hydrochloric acid and killed all of the Bacillus subtilis spores within 10 min. In addition, the acidic hypochlorite solution with acetic acid killed all of bacterial cells of Escherichia coli O157 : H 7, Legionella pneumophila, Pseudomonas aeruginosa, Salmonella Typhimurium and methicillin-resistant Staphylococcus aureus within 30 sec. On the other hand, the solutions prepared with citrate and lactate showed no bactericidal activity against any bacterial strains tested in this study despite of low pH. We proposed that acetic acid is a desirable acid to safely and easily prepare the acidic hypochlorite solution with the equivalent bactericidal activity to the solution prepared by HCl.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
58
4-5
開始ページ
234
終了ページ
235
並び順
234
発行日
2002-10-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系