ID 83837
著者
ネモト, ヒデユキ Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School|Genmai Koso Co., Ltd.
イカタ, カズエ Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School
有持 , 秀喜 Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
イワサキ, テルアキ Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School
大西, 克成 Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧
桑原, 知巳 Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School
片岡, 佳子 Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Molecular Bacteriology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
dietary fiber
fermented brown rice and rice bran
intestinal microbiota
organic acid
randomized controlled trial
資料タイプ
学術雑誌論文
抄録
Purpose : The aim of this study is to investigate the prebiotic effects of brown
rice fermented by Aspergillus oryzae (FBRA) on the intestinal environment in vitro and
in healthy adults. Methods : Fresh fecal slurries from six healthy adults were incubated
with FBRA to confirm prebiotic potentials of FBRA. Another thirty-six healthy adults
were randomly allocated to 2 groups for the clinical study. Subjects consumed 21.0 g/day
of either FBRA or control food for 2 weeks, followed by a 12-week intermission and then
2-week ingestion vice versa. Main outcome measures were bifidobacterial numbers and
organic acid concentration in feces. Sub outcome measures were fecal microbiota, fecal
environments and bowel function. Results : Incubation of fecal slurries with FBRA in
vitro resulted in increased organic acids with individual-specific patterns. Bifidobacterial
numbers were increased during incubation. In the clinical study, all participants
safely completed this study. FBRA had little effect on fecal number of bifidobacteria, concentrations
of organic acids or putrefactive metabolites, fecal pH, or fecal microbiota.
Conclusion : FBRA has the potentials as a prebiotic, however, we could not detect its
effects on the intestinal environment in vivo. The results in a clinical study indicated that
FBRA could be safely used for healthy adults.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
58
3-4
開始ページ
235
終了ページ
245
並び順
235
発行日
2011-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
部局
医学系