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ID 111713
タイトル別表記
シェーグレン症候群疾患モデルマウスにおける眼病変の病理学的解析
著者
牛尾, 綾 徳島大学大学院口腔科学教育部(口腔科学専攻)
江口, 洋 Sakai Hospital Kindai University KAKEN研究者をさがす
Hotta, Fumika Sakai Hospital Kindai University
キーワード
Sjögren’s Syndrome
dry eye
lacrimal glands
cytokine
chemokine
keratoconjunctivitis
tears
資料タイプ
学位論文
抄録
Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by severe inflammation of exocrine glands such as the salivary and lacrimal glands. When it affects the lacrimal glands, many patients experience keratoconjunctivitis due to severely dry eyes. This study investigated the pathological and immunological characteristics of ocular lesions in a mouse model of SS. Corneal epithelial injury and hyperplasia were confirmed pathologically. The number of conjunctival mucin-producing goblet cells was significantly decreased in the SS model mice compared with control mice. Expression levels of transforming growth factor (TGF)-β, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and C-X-C motif chemokine (CXCL) 12 were significantly higher in the corneal epithelium of the SS model mice than in control mice. Inflammatory lesions were observed in the Harderian, intraorbital, and extraorbital lacrimal glands in the SS model mice, suggesting that the ocular glands were targeted by an autoimmune response. The lacrimal glands of the SS model mice were infiltrated by cluster of differentiation (CD)4+ T cells. Real-time reverse transcription-polymerase chain reaction (RT-PCR) revealed significantly increased mRNA expression of TNF-α, TGF-β, CXCL9, and lysozyme in the extraorbital lacrimal glands of the SS model mice compared with control mice. These results add to the understanding of the complex pathogenesis of SS and may facilitate development of new therapeutic strategies.
掲載誌名
International Journal of Molecular Sciences
ISSN
14220067
16616596
cat書誌ID
AA12038549
出版者
MDPI
18
6
開始ページ
1209
発行日
2017-06-06
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Aya Ushioの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/ ).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3173号
学位記番号
甲口第430号
学位授与年月日
2018-03-23
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系
病院