ID 83490
著者
橋本, 一郎 Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
中西, 秀樹 Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ショウノ, ヨシタカ Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine
タナカ, シンジ Department of Plastic and Reconstructive Surgery, University Hospital, The University of Tokushima School of Medicine
キーワード
rabbit ear chamber
desferrioxamine
thrombus formation
microcirculation
資料タイプ
学術雑誌論文
抄録
We investigated the effects of the iron chelator desferrioxamine (DFX) on thrombus formation in the arterioles and venules of the rabbit ear chamber. Thrombi were induced by irradiation with filtered light in combination with a fluorescent dye. The occlusive thrombus formation time was significantly extended by DFX. The mor-phological composition of thrombi in the arterioles and venules was different. In the arterioles, the thrombi consisted of platelet aggregation, but in the venules, platelets and leukocytes accumulated on the endothelium. This suggests that hydroxyl radicals may be important mediators in this model, as DFX is known as a hydroxyl radical scav-enger. Furthermore, the components of thrombi in the arterioles and venules in the skin microvascular system may be different.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
46
3-4
開始ページ
200
終了ページ
204
並び順
200
発行日
1999
備考
EDB ID
フルテキストファイル
言語
eng
部局
医学系