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ID 115829
タイトル別表記
A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single photon emission computed tomography
著者
Bando, Ryota Tokushima University
Matsuda, Noritake Tokushima University
Azane, Shota Tokushima University
Kunikane, Yamato Tokushima University
キーワード
Active dopamine transporter volume
Dopamine transporter SPECT
Functional dopamine transporter volume
Parkinson syndrome
SUV
資料タイプ
学術雑誌論文
抄録
Objective
Dopamine transporter single-photon emission computed tomography (DAT SPECT) has been widely used to diagnose Parkinson syndrome. Using the standardized uptake value (SUV) of DAT SPECT, we propose “functional dopamine transporter volume (f-DTV)” as a new quantitative index to evaluate the three-dimensional volume of functional dopamine transporters and assess its diagnostic ability in differentiating dopaminergic neurodegenerative diseases (dNDD) from non-dNDD.
Methods
Seventy-nine patients were enrolled (42 dNDD, 37 non-dNDD; 38 men; age, 24–88 years). We analyzed seven quantitative indices. The specific binding ratio (SBR) was calculated using a program specialized for DAT SPECT (SBR_Bolt). The SUVmax, SUVpeak, and SUVmean were calculated using a quantification program for bone SPECT. SBR_SUV was calculated by dividing striatal SUVmean by the average of background SUVmean. The cutoff value of the active dopamine transporter level was examined using three methods (threshold of 40% of SUVmax, SUV 2, and SUV 3) to calculate the active dopamine transporter volume (ADV). The f-DTV was calculated by multiplying ADV and SUVmean. We assessed the correlations between SBR_Bolt and SBR_SUV, and compared the mean value of each index between the dNDD and non-dNDD groups. The abilities of SBR_Bolt, SBR_SUV, SUVmax, SUVpeak, SUVmean, ADV, and f-DTV in differentiating dNDD from non-dNDD were determined by the area under the receiver operating curve (AUC) generated by the receiver operating characteristics analysis.
Results
The SBR_Bolt and SBR_SUV highly correlated each other (r = 0.71). The cutoff value of the active dopamine transporter level was determined as SUV 3. All seven quantitative indices showed lower values in the dNDD group than in the non-dNDD group, and the difference between the two groups was statistically significant (p<0.05). Sensitivity, specificity, and AUC of f-DTV were slightly lower than those of SBR_Bolt (71%, 79%, and 0.81, respectively, for f-DTV, and 81%, 84%, 0.88, respectively, for SBR_Bolt). The difference in AUC between f-DTV and SBR_Bolt was not statistically significant.
Conclusions
This study demonstrates the utility of f-DTV as a novel quantitative index for evaluating the three-dimensional volume of functional dopamine transporters, and that f-DTV has almost the same diagnostic ability to differentiate dNDD from non-dNDD using DAT SPECT.
掲載誌名
Annals of Nuclear Medicine
ISSN
09147187
18646433
cat書誌ID
AA10708017
出版者
The Japanese Society of Nuclear Medicine|Springer Nature
35
4
開始ページ
504
終了ページ
513
発行日
2021-02-25
備考
This is a post-peer-review, pre-copyedit version of an article published in Annals of Nuclear Medicine. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12149-021-01592-w.
論文本文は2022-02-25以降公開予定
EDB ID
出版社版DOI
出版社版URL
言語
eng
著者版フラグ
その他
部局
医学系
放射線総合センター
病院