ID 106057
著者
ナカヤマ, タイスケ Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School
キノシタ, ハジメ Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
菅野, 幹雄 Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
黒部, 裕嗣 Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
神原, 保 Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
藤本, 鋭貴 Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
北市, 隆 Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
フジタ, ヒロシ Imabari Daiichi Hospital
ソガベ, ヒトシ Imabari Daiichi Hospital
北川, 哲也 Department of Cardiovascular Surgery, Institute for Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
heparin-induced thrombocytopenia
aortic surgery
unfractionated heparin
heparin-platelet factor 4 complex
argatroban
資料タイプ
学術雑誌論文
抄録
An extremely rare case with delayed-onset heparin-induced thrombocytopenia (HIT) is described. A 46-year-old man underwent arch replacement for aortic dissection under cardiopulmonary bypass and initial exposure of unfractionated heparin. In post operative 7 days, persistent atrial fibrillation was occurred, so a continuous infusion of heparin (10000 IU/day) and Vitamine K antagonist (Warfarin) taking was started for preventing thrombosis. By 32 days after the operation, his platelet count had fallen (3×103 /μL) and oral hematoma and ecchymoma of bilateral lower legs were occurred. The value of HIT antibodies and the IgG antibody was 2.485 and 1.586 on 32-postoperative day, respectively. Heparin was immediately discontinued, and argatroban administrated. Platelet exceeded above 100×103/μL on 12 days of the therapy. To our knowledge, few cases of delayed-onset severe HIT associated with CPB surgery have been reported in Japan.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
1-2
開始ページ
154
終了ページ
158
並び順
154
発行日
2013-02
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系