直近一年間の累計
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ID 117978
タイトル別表記
Tumor-induced osteomalacia diagnosed by somatostatin receptor scintigraphy and percutaneous venous blood sampling for FGF23 : A case report.
経皮静脈サンプリングで責任腫瘍を同定した腫瘍性骨軟化症の一例
著者
鈴木, 杏奈 徳島大学
浅井, 孝仁 徳島大学
答島, 悠貴 徳島大学
三井, 由加里 徳島大学
吉田, 守美子 徳島大学|四国こどもとおとなの医療センター KAKEN研究者をさがす
キーワード
FGF23
tumor-initiated osteomalacia (TIO)
percutaneous venous blood sampling
資料タイプ
学術雑誌論文
抄録
We report a case of 57-year-old-female with progressive bone pain and proximal dominant muscle weakness. Laboratory test revealed hypophosphatemia with decreased TmP/GFR, high bone-type ALP and elevated levels of FGF23. Radiograph and CT examination revealed multiple fracture with decreased levels of bone mineral density. She also had 2 cm of subcutaneous elastic soft tumor which located on the base of left big toe. Moreover, somatostatin receptor scintigraphy revealed increase uptake in the tumor with high suspicion of the culprit tumor of tumor-induced osteomalacia (TIO). To verify that the tumor generates FGF23, we performed percutaneous venous blood sampling. The FGF23 level in the left dorsal vein of foot was highest those in other veins. These results strongly suggested that the tumor produced FGF23 and was the culprit tumor for the disorder. The patient underwent resection of the tumor. One day after surgery, the serum FGF23 level in a peripheral vein decreased to less than the measurement sensitivity, while serum phosphate improved to normal range. Two months of following surgery, clinical and biochemical examinations confirmed the successful of operation. Although it is sometimes difficult to detect the culprit tumors in TIO cases, a combination of localization studies may improve diagnostic accuracy of the culprit tumors. Furthermore, percutaneous peripheral venous sampling would be clinically useful for cases who have the responsible tumor located on limbs, hands and feet.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
78
5-6
開始ページ
227
終了ページ
234
並び順
227
発行日
2022-12-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
医学系
先端酵素学研究所