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ID 115932
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血液がん患者の好中球減少に伴う発熱の危険因子としての口腔細菌および口腔免疫との関連
Risk factors for chemotherapy-induced fever with neutropenia
著者
十川, 悠香 徳島大学大学院口腔科学教育部(口腔保健学専攻)
吉岡, 昌美 Tokushima Bunri University KAKEN研究者をさがす
キーワード
Fever with neutropenia
Hematological cancer
Risk factor
Secretory immunoglobulin A
Fusobacterium nucleatum
資料タイプ
学位論文
抄録
The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1,500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject was assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p<0.05) and the rate of Fusobacterium nucleatum [F. nucleatum count per total bacterial count (%)] was high (HR 1.65, p<0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cut-off point based on the AUC in the F. nucleatum / sIgA ratio was 0.023, and this model had a 78.4% probability (p<0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023 F. nucleatum / sIgA ratio (HR 66.06, p<0.01). These results suggest that the rate of F. nucleatum and the levels of sIgA at baseline might be related to FwN onset as risk factors.
掲載誌名
International Journal of Hematology
ISSN
09255710
18653774
cat書誌ID
AA10797094
出版者
Japanese Society of Hematology|Springer Nature
112
6
開始ページ
851
終了ページ
859
発行日
2020-09-03
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuka Sogawaの学位論文として提出され,学位審査・授与の対象となっている。
著者の申請により要約(2021-04-27公開)に替えて論文全文を公開(2022-12-16)
権利情報
© Japanese Society of Hematology 2020
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12185-020-02975-x
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3472号
学位記番号
甲口保第5号
学位授与年月日
2021-02-08
学位名
博士(口腔保健学)
学位授与機関
徳島大学
部局
歯学系
医学系
病院