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ID 106037
著者
キシモト, トモテル Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School
布川, 朋也 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
山口, 邦久 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
山本, 恭代 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ナカツジ, ヒロヨシ Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School
井崎, 博文 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
高橋, 正幸 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
福森, 知治 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
金山, 博臣 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
11-beta-hydroxysteroid dehydrogenase type 2
aldosterone
erectile dysfunction
mineralocorticoid receptor
penis
資料タイプ
学術雑誌論文
抄録
Objectives : Mineralocorticoid receptor (MR) is known to play physiological and pathophysiological roles in the cardiovascular system, and MR activation directly damages these organs. The aim of this study was to evaluate the expression of MR and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in the human penile corpus cavernosum. Methods : MR and 11β-HSD2 expression was assayed in human penile tissues, and also in human renal tissues as a positive control. Expressions of MR mRNA and 11β-HSD2 mRNA were evaluated using reverse transcription polymerase chain reaction (RT-PCR). MR and 11β-HSD2 were visually identified using immunofluorescence analysis. Results : MR mRNA expression in human penis was confirmed by RT-PCR. On quantitative RT-PCR analysis, 11β-HSD2 mRNA expression was detected at minimal levels in penile tissue. Immunofluorescence analysis revealed positive staining for MR and negative staining for 11β-HSD2 in smooth muscle cells of the corpus cavernosum. Conclusions : This study demonstrated the presence of MR and the absence of 11β-HSD2 in human penile corpus cavernosum. Considering that MR activation causes various organ damages, MR blockade in human penile corpus cavernosum may have therapeutic benefits. Investigations for the penile effects of MR activation have the potential to provide new treatment approaches for erectile dysfunction.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
60
1-2
開始ページ
21
終了ページ
26
並び順
21
発行日
2013-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院