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ID 109496
著者
山口, 邦久 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
井崎, 博文 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
高橋, 正幸 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
福森, 知治 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
西谷, 真明 Kawashima Hospital
ストウ, ヤスシ Tsurugi Municipality Handa Hospital
ウエマ, ケンゾウ Tokushima Red Cross Hospital
カワノ, アキラ Sanuki Municipal Hospital
ハマオ, タクミ Kamei Hospital
金山, 博臣 Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
hormone therapy
discontinuation
PSA value
testosterone level
PSA relapse
資料タイプ
学術雑誌論文
抄録
Introduction : We evaluated changes in levels of prostate-specific antigen (PSA) and testosterone following discontinuation of long-term hormone therapy for non-metastatic prostate cancer. Patients and Methods : Treatment was discontinued in 31 patients
with non-metastatic prostate cancer (clinical stage B-C) after≧5 years of hormone therapy, during which time PSA level had been maintained less than 0.5 ng/ml. PSA and testosterone levels were measured after discontinuation of therapy. PSA>4.0 ng/ml was defined as PSA relapse in this study. Results : Mean age at discontinuation of hormone therapy was 78.7 years (range, 66-90). Mean duration of follow-up after discontinuation of therapy was 25.5 months. PSA non-relapse rate was quite high (87.1%). 4 of the 31 patients showed PSA relapse, after 12-24 months. Testosterone level exceeded castration level (<1.0 ng/ml) in 3 patients, each of whom developed PSA relapse. Conclusions : During follow-up, the PSA relapse rate was relatively low. These results suggest that treatment may be safely discontinued in many prostate cancer patients. In addition, rate of testosterone recovery after treatment discontinuation may be associated with PSA relapse. When considered the adaptation of discontinued, or intermittent hormone therapy for aged people, these findings may be useful.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
1-2
開始ページ
35
終了ページ
40
並び順
35
発行日
2014-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院