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ダウンロード数 : ?
ID 110846
著者
タニモト, シュウジ Department of Urology, Takamatsu Red Cross Hospital
福森, 知治 Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
El-Moula, Gad Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Shiirevnyamba, Avirmed Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
キノウチ, シンイチロウ Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
コイズミ, タカヒロ Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
ナカニシ, リョウイチ Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
山本, 恭代 Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
タウエ, リュウイチ Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
山口, 邦久 Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ナカツジ, ヒロヨシ Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
キシモト, トモテル Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
井崎, 博文 Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
オカ, ナツオ Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
高橋, 正幸 Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
金山, 博臣 Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
renal cell carcinoma
hepatocyte growth factor
vascular endothelial growth factor
prognostic maker
diagnostic maker
資料タイプ
学術雑誌論文
抄録
No adequate serum predictive biomarker currently exists, which can identify the activity of renal cell carcinoma (RCC). We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. We measured serum levels of HGF and VEGF in 45 patients with untreated clear cell RCC and 45 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Patients with clear cell RCC had significantly higher serum HGF and VEGF concentrations than healthy subjects : median, 1070.7 versus 728.3 pg/ml (p<0.0001) for HGF and median, 397.5 versus 245.6 pg/ml (p=0.0003) for VEGF. We found a significant correlation between serum level of HGF and clinical stage and tumor grade. Survival of patients with high serum HGF (>1150 pg/ml) was significantly reduced compared to patients with low serum HGF concentrations (p=0.0044). In patients with nuclear grade 2 or high stage RCC, the higher serum HGF group exhibited significantly lower cause-specific survival (p= 0.0087 and p<0.05, respectively). No significant difference was observed between serum VEGF levels and cause-specific survival rate. Serum HGF might be a diagnostic and prognostic indicator in clear cell RCC, especially for patients with grade 2 or high stage RCC.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
1-2
開始ページ
106
終了ページ
111
並び順
106
発行日
2008-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系