アクセス数 : ?
ダウンロード数 : ?
ID 114556
タイトル別表記
Metabolic remodeling of hyperactive rats
著者
Miyatake, Yumiko Tokushima University|Wakayama Medical University
谷村, 綾子 Tokushima University|Prefectural University of Kumamoto KAKEN研究者をさがす
Hagita, Hiroko Tokushima University
キーワード
adenylate kinase
energy metabolism
microarray analysis
SPORTS rats
voluntary exercise
資料タイプ
学術雑誌論文
抄録
Spontaneously Running Tokushima Shikoku (SPORTS) rat is a hyperactive rat strain. However, the causative mutation of this phenotype has not yet been identified. To investigate the molecular basis for the unique phenotype of SPORTS rats, we examined gene-expression profiles by microarray analyses. Among adenylate kinase isozymes that maintain the homeostasis of cellular adenine nucleotide composition in the cell, only adenylate kinase 1 is highly up-regulated in both exercised and sedentary SPORTS rats compared with wild-type (WT) rats, 5.5-fold and 3.3-fold, respectively. Further comparative analyses revealed that genes involved in glucose metabolism were up-regulated in skeletal muscle tissue of exercised SPORTS rats compared with sedentary mutants, whereas genes related to extracellular matrix or region were down-regulated compared with WT rats. In brain tissue of sedentary SPORTS rats, genes associated with defense and catecholamine metabolism were highly expressed compared with WT rats. These findings suggest that genetic mutation(s) in SPORTS rat remodels metabolic demands through differentially regulating gene expression regardless of exercise. Therefore, the SPORTS rats are useful animal model not only for further examining the effects of exercise on metabolism but also for deeply studying the molecular basis how mutation affect the psychological motivation with spontaneous voluntary exercise phenotype.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Tokushima University Faculty of Medicine
67
1-2
開始ページ
51
終了ページ
61
並び順
51
発行日
2020-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系