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ダウンロード数 : ?
ID 110675
著者
林, 良夫 Department of Pathology, Tokushima University School of Dentistry 徳島大学 教育研究者総覧 KAKEN研究者をさがす
新垣, 理恵子 Department of Pathology, Tokushima University School of Dentistry 徳島大学 教育研究者総覧 KAKEN研究者をさがす
石丸, 直澄 Department of Pathology, Tokushima University School of Dentistry 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Sjögren’s syndrome
autoantigen
caspase
apoptosis
資料タイプ
学術雑誌論文
抄録
Primary Sjögren syndrome (SS) is an autoimmune disease characterized by diffuse lymphoid cell infiltrates in the salivary and lacrimal glands, resulting in symptoms of dry eye and dry mouth due to insufficient secretion. Previously, we have identified the120 kDa α-fodrin as an important autoantigen on the development of SS in both animal model and SS patients, but the mechanism of α-fodrin cleavage leading to tissue destruction in SS remains unclear. In murine primary SS model, tissue-infiltrating CD4+ T cells purified from the salivary glands bear a large proportion of Fas ligand (FasL), and the salivary gland duct cells constitutively possess Fas. Infiltrating CD4+ T cells identified significant51Cr release against mouse salivary gland (MSG) cells. In vitro studies demonstrated that apoptotic MSG cells result in a specific α-fodrin cleavage into 120 kDa, and preincubation with caspase-inhibitor peptides blocked α-fodrin cleavage. The treatment with caspase-inhibitors in vivo prevented the development of autoimmune lesions in the salivary and lacrimal glands. Thus, an increased activity in caspase cascade may be involved in the progression of α-fodrin proteolysis and tissue destruction on the development of SS.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
50
1-2
開始ページ
32
終了ページ
38
並び順
32
発行日
2003
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系