ID 113529
タイトル別表記
Impaired Function of Treg Cells
著者
資料タイプ
学術雑誌論文
抄録
Neonatal thymectomy (Tx) in certain mouse strains is known to induce organ-specific autoimmunity due to impaired functions of T cells, including Foxp3+ regulatory T (Treg) cells in the thymus. The precise mechanism underlying the induction of autoimmunity by neonatal Tx remains unclear. One possibility is that depletion of Treg cells breaks down peripheral tolerance. We examined the functions of Treg cells by using a murine Sjögren’s syndrome (SS) model, NFS/sld mice that underwent neonatal Tx. The ratio of Treg cells to effector memory phenotype T cells in Tx mice was significantly lower than that of non-Tx mice. In addition, in vitro induction of peripherally induced Treg cells by transforming growth factor-β (TGF-β) using naïve T cells from SS model mice was severely impaired. The mRNA expression of TGF-β receptor I, II, and Smad3 and -4 in the TGF-β-induced signal transduction pathway of Treg cells in this SS model were lower than those of control mice. In addition, Treg cells in this SS model exhibited an IFN-γ-producing Th1-like phenotype that resembled effector T cells. In conclusion, these results suggest that abnormal expansion and differentiation of Treg cells and inflammatory cytokines produced by Treg cells contribute to the development of autoimmunity.
掲載誌名
The American Journal of Pathology
ISSN
00029440
15252191
cat書誌ID
AA00520990
AA12024839
出版者
American Society for Investigative Pathology|Elsevier
185
11
開始ページ
2886
終了ページ
2897
発行日
2015-09-04
権利情報
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
歯学系
医学系