ID 109765
タイトルヨミ
コウクウ サイキン ノ ネツ ショック タンパクシツ ト ソノ シシュウビョウ エノ カンヨ
タイトル別表記
Heat Shock Proteins from Oral Bacteria and Their Potential Contributions to Periodontal Disease
著者
日野出, 大輔 徳島大学歯学部口腔保健学科口腔保健基礎学講座 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
口腔細菌
熱ショック蛋白質
歯周病
資料タイプ
学術雑誌論文
抄録
The oral cavity is subjected to a wide range of environmental changes such as heat stress that may affect the biology of oral bacteria. Bacterial heat shock proteins (HSPs), especially, GroEL protein is one of immunodoninant antigen in infection. The high degree of conservation of GroEL implies that molecular mimicry may occur, antibodies against microbial GroEL can cross-react with host HSP60 antigens. Several groups showed that GroEL proteins from periodontopathogenic bacteria were immunodoninant serum antigens in patients with periodontitis. It also revealed in our study the immunologic cross-reactivity between human fibronectin and Actinobacillus actinomycetmcomitans GroEL. These phenomena may lead to an autoimmune response and contribute to tissue destruction during periodontitis. On the other hand, Campylobacter rectus GroEL and A. actinomycetmcomitans GroEL possessed the ability to stimulate production of interleukin (IL)-6 by a confluent monolayer of human gingival epithelial cells and gingival fibroblasts. This result clearly indicates that GroEL proteins play a role in initiation and progression of periodontal disease. Interestingly, salivary IgA antibody directed to C. rectus GroEL from patients with priodontitis caused a partial inhibition of IL-6 production. Salivary IgA may have a protective role by reducing the inflammatory response induced by oral microbial GroEL. I review here the several reports regarding HSPs from oral bacteria and demonstrate their potential contributions to periodontal disease.
掲載誌名
四国歯学会雑誌
ISSN
09146091
cat書誌ID
AN10050046
出版者
四国歯学会
20
2
開始ページ
215
終了ページ
221
並び順
215
発行日
2008-01-31
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
歯学系