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ID 109707
タイトル別表記
自己免疫疾患モデルにおけるM1マクロファージ不全と血管新生を介した腫瘍増殖の亢進
Cross-talk between autoimmunity and tumor immunity
著者
近藤, 智之 徳島大学大学院口腔科学教育部(口腔科学専攻)
Kujiraoka, Satoko Tokushima University
牛尾, 綾 Tokushima University
Kurosawa, Mie Tokushima University
キーワード
Autoimmunity
Cancer
Tumor associated macrophage
Angiogenesis
Tumor immunity
資料タイプ
学位論文
抄録
Both autoimmunity and tumor immunity are immune responses against self-tissues or cells. However, the precise similarity or difference between them remains unclear. In this study, to understand a novel mechanism of tumor immunity, we performed transplantation experiments with a murine autoimmune model, C57BL/6J (B6)/lpr mice. A melanoma cell line, B16F10 cells, or granulocyte macrophage colony-stimulating factor- overexpressing B16F10 (B16F10/mGM) cells were transplanted into B6 or B6/lpr mice. Tumor growth by transplanted B16F10/mGM cells was significantly accelerated in B6/lpr mice compared with that in B6 mice. The accumulation of M1 macrophages in the tumor tissues of B6/lpr recipient mice was significantly lower compared with that in the control mice. In vitro co-culture experiment showed that impaired differentiation into M1 macrophages was observed in B6/lpr mice. The number of tumor vessels and vascular endothelial growth factor (VEGF) expression were also significantly enhanced in the tumor tissues of B6/lpr mice compared with those in the B6 mice. Moreover, VEGF expression was correlated with the increased expression of hypoxia-inducible factor-1α in the tumor tissues of B6/lpr mice. These results suggest that dysfunctional tumor immunity and enhanced angiogenesis in autoimmunity influence tumor growth.
掲載誌名
Laboratory Investigation
ISSN
15300307
cat書誌ID
AA12189985
出版者
Springer nature
96
4
開始ページ
468
終了ページ
480
発行日
2016-01-25
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201606141010.pdf
審査要旨 : LID201606141011.pdf
論文本文 : k2943_fulltext.pdf
著者の申請により要約(2016-06-15公開)に替えて論文全文を公開(2019-06-05)

本論文は, 著者Tomoyuki Kondoの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
This is the Author's Accepted Manuscript of the following article: Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease, Tomoyuki Kondo, Takaaki Tsunematsu, Akiko Yamada, Rieko Arakaki, Masako Saito, Kunihiro Otsuka, Satoko Kujiraoka, Aya Ushio, Mie Kurosawa, Yasusei Kudo & Naozumi Ishimaru, Laboratory Investigation 96, 468-480 (2016), which has been published in final form at https://doi.org/10.1038/labinvest.2015.166.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2943号
学位記番号
甲口第408号
学位授与年月日
2016-03-23
学位名
博士(歯学)
学位授与機関
徳島大学
部局
医学系
歯学系