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ID 109872
タイトルヨミ
ダエキセン ノ コウゾウ ト キノウ
タイトル別表記
Structure and Function of the Salivary Gland
著者
赤松, 徹也 徳島大学大学院医歯薬学研究部口腔分子生理学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
唾液腺
唾液
水チャネル
サチライシン様前駆体蛋白質変換酵素
資料タイプ
学術雑誌論文
抄録
The salivary gland is developed under the epithelial-mesenchymal interaction and formed by repeating branching morphogenesis, which is a common process in the development of the glandular tissues. Although the differentiation and maturation of salivary gland is continued into early postnatal life, the fundamental ability of saliva secretion is already expressed after birth.
These development, differentiation, and maturation of salivary gland are regulated by many growth/ differentiation factors, which are initially synthesized as inactive precursors and activated by the limited proteolysis. On the other hand, saliva secretion is one of the important physiological functions of the salivary gland and occurs dependently on the increase of the osmolality in the lumen through two pathways, paracellular and transcellular pathways. It is revealed that a water channel aquaporin 5 (AQP5) is involved in saliva secretion through the latter pathway. Saliva contains various components, which express various physiological functions of saliva. Because the oral cavity is confronted with hazards of various allergens from the outside continuously, the salivary gland produces and secretes various factors as the defense system. Saliva is, therefore, one of an important body fluid to maintain the oral health, and the decrease of saliva secretion causes xerostomia/dry mouth, which affects not only oral disease and dysfunction but also systemic disease. We previously reported the involvement of a subtilisin-like proprotein convertase PACE4 in the development and differentiation of salivary gland, lipopolysaccharide-mediated induction of inflammatory cytokines in the salivary gland, degradation of salivary AQP5 by parasympathetic denervation, and so on. This review will describe the structure and function of the salivary gland, from its development to functional expression and regulation.
掲載誌名
Journal of Oral Health and Biosciences
ISSN
21887888
cat書誌ID
AA12713630
出版者
四国歯学会
28
2
開始ページ
77
終了ページ
86
並び順
77
発行日
2016-02-29
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
生物資源系