Hara, Kanae Tokushima University
藤澤, 健司 Tokushima University KAKEN研究者をさがす
永井, 宏和 Tokushima University KAKEN研究者をさがす
髙丸, 菜都美 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
大江, 剛 Tokushima University KAKEN研究者をさがす
Tsuru, Kanji Kyushu University
Ishikawa, Kunio Kyushu University
宮本, 洋二 Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
interconnected porous structure
Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin; however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam.
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
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