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タイトル別表記
PETを用いたレディオミクス解析による舌扁平上皮癌の頸部リンパ節転移の予測
著者
工藤, 隆治 徳島大学大学院口腔科学研究科(口腔科学専攻) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Tongue squamous cell carcinoma
Cervical lymph node metastasis
Radiomics
[18F]-fluoro-2-deoxyglucose
Positron emission tomography
資料タイプ
学位論文
抄録
Objectives
This study aimed to create a predictive model for cervical lymph node metastasis (CLNM) in patients with tongue squamous cell carcinoma (SCC) based on radiomics features detected by [18F]-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET).
Methods
A total of 40 patients with tongue SCC who underwent 18F-FDG PET imaging during their first medical examination were enrolled. During the follow-up period (mean 28 months), 20 patients had CLNM, including six with late CLNM, whereas the remaining 20 patients did not have CLNM. Radiomics features were extracted from 18F-FDG PET images of all patients irrespective of metal artifact, and clinicopathological factors were obtained from the medical records. Late CLNM was defined as the CLNM that occurred after major treatment. The least absolute shrinkage and selection operator (LASSO) model was used for radiomics feature selection and sequential data fitting. The receiver operating characteristic curve analysis was used to assess the predictive performance of the 18F-FDG PET-based model and clinicopathological factors model (CFM) for CLNM.
Results
Six radiomics features were selected from LASSO analysis. The average values of the area under the curve (AUC), accuracy, sensitivity, and specificity of radiomics analysis for predicting CLNM from 18F-FDG PET images were 0.79, 0.68, 0.65, and 0.70, respectively. In contrast, those of the CFM were 0.54, 0.60, 0.60, and 0.60, respectively. The 18F-FDG PET-based model showed significantly higher AUC than that of the CFM.
Conclusions
The 18F-FDG PET-based model has better potential for diagnosing CLNM and predicting late CLNM in patients with tongue SCC than the CFM.
掲載誌名
Oral Radiology
ISSN
09116028
16139674
cat書誌ID
AA10689728
出版者
Japanese Society for Oral and Maxillofacial Radiology|Springer Nature
発行日
2022-03-07
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takaharu Kudohの学位論文として提出され,学位審査・授与の対象となっている。
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11282-022-00600-7
論文本文は2023-03-07以降公開予定
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
jpn
著者版フラグ
その他
文科省報告番号
甲第3643号
学位記番号
甲口第487号
学位授与年月日
2022-07-15
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系
医学系
病院